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Polypropylene mesh coated with hyaluronic acid/polyvinyl alcohol composite hydrogel for preventing bowel adhesion.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 270 (Pt 1), pp. 132061. Date of Electronic Publication: 2024 May 03. - Publication Year :
- 2024
-
Abstract
- Polypropylene (PP) mesh is the most widely used prosthetic material in hernia repair. However, the efficacy of implanted PP mesh is often compromised by adhesion between viscera and PP mesh. Thus, there is a recognized need for developing an anti-adhesive PP mesh. Here, a composite hydrogel coated PP mesh with the prevention of adhesion after hernia repair was designed. The composite hydrogel coating was prepared from polyvinyl alcohol (PVA) and hyaluronic acid (HA) by using the freezing-thawing (FT) method. To overcome the shortcoming of the long time of the traditional freezing-thawing method, a small molecule 3,4-dihydroxyphenylacetic acid (DHPA) was introduced to promote the formation of composite hydrogel. The as-prepared composite hydrogel coating displayed modulus more closely resembling that of native abdominal wall tissue. In vitro studies illustrated that the resulting meshes showed excellent coating stability, hemocompatibility, and non-cytotoxicity. In vivo experiments using a rat abdominal wall defect model demonstrated that the composite hydrogel coated PP mesh could prevent the formation of adhesion, alleviate the inflammatory response, and reduce the deposition of collagen around the damaged tissue. These disclosed results manifested that the PP mesh coated with HA/PVA composite hydrogel might be a promising application in preventing adhesion for hernia repair.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Rats
Tissue Adhesions prevention & control
Hydrogels chemistry
Hydrogels pharmacology
Male
Abdominal Wall surgery
Humans
Rats, Sprague-Dawley
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Materials Testing
Herniorrhaphy methods
Hyaluronic Acid chemistry
Hyaluronic Acid pharmacology
Polyvinyl Alcohol chemistry
Polypropylenes chemistry
Surgical Mesh
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 270
- Issue :
- Pt 1
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38705326
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.132061