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The molecular basis of phenotypic evolution: beyond the usual suspects.
- Source :
-
Trends in genetics : TIG [Trends Genet] 2024 Aug; Vol. 40 (8), pp. 668-680. Date of Electronic Publication: 2024 May 03. - Publication Year :
- 2024
-
Abstract
- It has been well documented that mutations in coding DNA or cis-regulatory elements underlie natural phenotypic variation in many organisms. However, the development of sophisticated functional tools in recent years in a wide range of traditionally non-model systems have revealed many 'unusual suspects' in the molecular bases of phenotypic evolution, including upstream open reading frames (uORFs), cryptic splice sites, and small RNAs. Furthermore, large-scale genome sequencing, especially long-read sequencing, has identified a cornucopia of structural variation underlying phenotypic divergence and elucidated the composition of supergenes that control complex multi-trait polymorphisms. In this review article we highlight recent studies that demonstrate this great diversity of molecular mechanisms producing adaptive genetic variation and the panoply of evolutionary paths leading to the 'grandeur of life'.<br />Competing Interests: Declaration of interests The authors have no conflicts of interest to declare.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0168-9525
- Volume :
- 40
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in genetics : TIG
- Publication Type :
- Academic Journal
- Accession number :
- 38704304
- Full Text :
- https://doi.org/10.1016/j.tig.2024.04.010