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Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory-based approach.
- Source :
-
Brain and behavior [Brain Behav] 2024 May; Vol. 14 (5), pp. e3504. - Publication Year :
- 2024
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Abstract
- Background: Electroacupuncture (EA) has been shown to facilitate brain plasticity-related functional recovery following ischemic stroke. The functional magnetic resonance imaging technique can be used to determine the range and mode of brain activation. After stroke, EA has been shown to alter brain connectivity, whereas EA's effect on brain network topology properties remains unclear. An evaluation of EA's effects on global and nodal topological properties in rats with ischemia reperfusion was conducted in this study.<br />Methods and Results: There were three groups of adult male Sprague-Dawley rats: sham-operated group (sham group), middle cerebral artery occlusion/reperfusion (MCAO/R) group, and MCAO/R plus EA (MCAO/R + EA) group. The differences in global and nodal topological properties, including shortest path length, global efficiency, local efficiency, small-worldness index, betweenness centrality (BC), and degree centrality (DC) were estimated. Graphical network analyses revealed that, as compared with the sham group, the MCAO/R group demonstrated a decrease in BC value in the right ventral hippocampus and increased BC in the right substantia nigra, accompanied by increased DC in the left nucleus accumbens shell (AcbSh). The BC was increased in the right hippocampus ventral and decreased in the right substantia nigra after EA intervention, and MCAO/R + EA resulted in a decreased DC in left AcbSh compared to MCAO/R.<br />Conclusion: The results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke.<br /> (© 2024 The Authors. Brain and Behavior published by Wiley Periodicals LLC.)
- Subjects :
- Animals
Male
Rats
Brain physiopathology
Brain diagnostic imaging
Brain Ischemia therapy
Brain Ischemia physiopathology
Brain Ischemia diagnostic imaging
Disease Models, Animal
Nerve Net physiopathology
Nerve Net diagnostic imaging
Ischemic Stroke therapy
Ischemic Stroke physiopathology
Ischemic Stroke diagnostic imaging
Hippocampus diagnostic imaging
Hippocampus physiopathology
Electroacupuncture methods
Rats, Sprague-Dawley
Reperfusion Injury physiopathology
Reperfusion Injury therapy
Reperfusion Injury diagnostic imaging
Infarction, Middle Cerebral Artery therapy
Infarction, Middle Cerebral Artery physiopathology
Infarction, Middle Cerebral Artery diagnostic imaging
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2162-3279
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Brain and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 38698583
- Full Text :
- https://doi.org/10.1002/brb3.3504