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Clinical outcomes of endoscopic resection for the treatment of intermediate- or high-risk gastric small gastrointestinal stromal tumors: a multicenter retrospective study.
- Source :
-
Surgical endoscopy [Surg Endosc] 2024 Jun; Vol. 38 (6), pp. 3353-3360. Date of Electronic Publication: 2024 May 02. - Publication Year :
- 2024
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Abstract
- Background and Aims: Many studies of gastric gastrointestinal stromal tumors (g-GISTs) following endoscopic resection (ER) have typically focused on tumor size, with most tumors at low risk of aggressiveness after risk stratification. There have been few systematic studies on the oncologic outcomes of intermediate- or high-risk g-GISTs after ER.<br />Methods: From January 2014 to January 2020, we retrospectively collected patients considered at intermediate- or high-risk of g-GISTs according to the modified NIH consensus classification system. The primary outcome was overall survival (OS).<br />Results: Six hundred and seventy nine (679) consecutive patients were diagnosed with g-GISTs and treated by ER between January 2014 and January 2020 in three hospitals in Shanghai, China. 43 patients (20 males and 23 females) were confirmed at intermediate-or high-risk. The mean size of tumors was 2.23 ± 1.01 cm. The median follow-up period was 62.02 ± 15.34 months, with a range of 28 to 105 months. There were no recurrences or metastases, even among patients having R1 resections. The 5-year OS rate was 97.4% (42/43).<br />Conclusion: ER for intermediate- or high-risk gastric small GISTs is a feasible and safe method, which allows for a wait-and-see approach before determining the necessity for imatinib adjuvant or surgical treatment. This approach to g-GISTs does require that patients undergo close follow-up.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Aged
Adult
Treatment Outcome
Gastroscopy methods
Survival Rate
China epidemiology
Aged, 80 and over
Risk Assessment
Gastrectomy methods
Gastrointestinal Stromal Tumors surgery
Gastrointestinal Stromal Tumors pathology
Gastrointestinal Stromal Tumors mortality
Stomach Neoplasms surgery
Stomach Neoplasms pathology
Stomach Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2218
- Volume :
- 38
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Surgical endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 38698259
- Full Text :
- https://doi.org/10.1007/s00464-024-10753-7