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Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes.
- Source :
-
Journal of diabetes and its complications [J Diabetes Complications] 2024 Jun; Vol. 38 (6), pp. 108763. Date of Electronic Publication: 2024 Apr 30. - Publication Year :
- 2024
-
Abstract
- Managing complications in Type 1 diabetes (T1D) remains challenging. HLA genes, particularly DR and DQ, are linked to T1D susceptibility. We studied 48 Japanese T1D inpatients and revealed associations between DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 haplotypes and complications, offering a new perspective for future research.<br />Competing Interests: Declaration of competing interest The authors have nothing to disclose.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Adult
Japan epidemiology
HLA-DRB1 Chains genetics
HLA-DQ beta-Chains genetics
Middle Aged
Young Adult
Haplotypes
Asian People statistics & numerical data
Asian People genetics
Adolescent
Diabetic Neuropathies epidemiology
Diabetic Neuropathies genetics
Diabetic Neuropathies etiology
East Asian People
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 genetics
Diabetic Angiopathies epidemiology
Diabetic Angiopathies genetics
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1873-460X
- Volume :
- 38
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of diabetes and its complications
- Publication Type :
- Academic Journal
- Accession number :
- 38696976
- Full Text :
- https://doi.org/10.1016/j.jdiacomp.2024.108763