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Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women.
- Source :
-
Frontiers in public health [Front Public Health] 2024 Apr 17; Vol. 12, pp. 1371920. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Background: An increasing number of studies suggest that environmental pollution may increase the risk of vitamin D deficiency (VDD). However, less is known about arsenic (As) exposure and VDD, particularly in Chinese pregnant women.<br />Objectives: This study examines the correlations of different urinary As species with serum 25 (OH) D and VDD prevalence.<br />Methods: We measured urinary arsenite (As <superscript>3+</superscript> ), arsenate (As <superscript>5+</superscript> ), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) levels and serum 25(OH)D <subscript>2</subscript> , 25(OH)D <subscript>3</subscript> , 25(OH) D levels in 391 pregnant women in Tianjin, China. The diagnosis of VDD was based on 25(OH) D serum levels. Linear relationship, Logistic regression, and Bayesian kernel machine regression (BKMR) were used to examine the associations between urinary As species and VDD.<br />Results: Of the 391 pregnant women, 60 received a diagnosis of VDD. Baseline information showed significant differences in As <superscript>3+</superscript> , DMA, and tAs distribution between pregnant women with and without VDD. Logistic regression showed that As <superscript>3+</superscript> was significantly and positively correlated with VDD (OR: 4.65, 95% CI: 1.79, 13.32). Meanwhile, there was a marginally significant positive correlation between tAs and VDD (OR: 4.27, 95% CI: 1.01, 19.59). BKMR revealed positive correlations between As <superscript>3+</superscript> , MMA and VDD. However, negative correlations were found between As <superscript>5+</superscript> , DMA and VDD.<br />Conclusion: According to our study, there were positive correlations between iAs, especially As <superscript>3+</superscript> , MMA and VDD, but negative correlations between other As species and VDD. Further studies are needed to determine the mechanisms that exist between different As species and VDD.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Zhang, Bai, Chen, Li, Meng, Jia, Yang, Huang, Zhang and Zhang.)
- Subjects :
- Humans
Female
Pregnancy
Cross-Sectional Studies
China epidemiology
Adult
Prevalence
Arsenicals urine
Vitamin D blood
Vitamin D urine
Pregnancy Complications urine
Pregnancy Complications epidemiology
Logistic Models
East Asian People
Vitamin D Deficiency epidemiology
Vitamin D Deficiency urine
Arsenic urine
Arsenic blood
Subjects
Details
- Language :
- English
- ISSN :
- 2296-2565
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in public health
- Publication Type :
- Academic Journal
- Accession number :
- 38694994
- Full Text :
- https://doi.org/10.3389/fpubh.2024.1371920