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Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.
- Source :
-
Cells & development [Cells Dev] 2024 Sep; Vol. 179, pp. 203922. Date of Electronic Publication: 2024 Apr 28. - Publication Year :
- 2024
-
Abstract
- A vasculature network supplies blood to feather buds in the developing skin. Does the vasculature network during early skin development form by sequential sprouting from the central vasculature or does local vasculogenesis occur first that then connect with the central vascular tree? Using transgenic Japanese quail Tg(TIE1p.H2B-eYFP), we observe that vascular progenitor cells appear after feather primordia formation. The vasculature then radiates out from each bud and connects with primordial vessels from neighboring buds. Later they connect with the central vasculature. Epithelial-mesenchymal recombination shows local vasculature is patterned by the epithelium, which expresses FGF2 and VEGF. Perturbing noggin expression leads to abnormal vascularization. To study endothelial origin, we compare transcriptomes of TIE1p.H2B-eYFP <superscript>+</superscript> cells collected from the skin and aorta. Endothelial cells from the skin more closely resemble skin dermal cells than those from the aorta. The results show developing chicken skin vasculature is assembled by (1) physiological vasculogenesis from the peripheral tissue, and (2) subsequently connects with the central vasculature. The work implies mesenchymal plasticity and convergent differentiation play significant roles in development, and such processes may be re-activated during adult regeneration. SUMMARY STATEMENT: We show the vasculature network in the chicken skin is assembled using existing feather buds as the template, and endothelia are derived from local bud dermis and central vasculature.<br />Competing Interests: Declaration of competing interest The authors declare no competing financial interests.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Animals
Dermis blood supply
Dermis metabolism
Mesoderm metabolism
Feathers
Endothelial Cells metabolism
Endothelial Cells cytology
Animals, Genetically Modified
Gene Expression Regulation, Developmental
Coturnix embryology
Chick Embryo
Cell Differentiation genetics
Skin blood supply
Skin metabolism
Neovascularization, Physiologic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2667-2901
- Volume :
- 179
- Database :
- MEDLINE
- Journal :
- Cells & development
- Publication Type :
- Academic Journal
- Accession number :
- 38688358
- Full Text :
- https://doi.org/10.1016/j.cdev.2024.203922