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The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107400. Date of Electronic Publication: 2024 Apr 25. - Publication Year :
- 2024
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Abstract
- Although certain members of the Ubiquitin-specific peptidases (USPs) have been recognized as promising therapeutic targets for various diseases, research progress regarding USP21 has been relatively sluggish in its early stages. USP21 is a crucial member of the USPs subfamily, involved in diverse cellular processes such as apoptosis, DNA repair, and signal transduction. Research findings from the past decade demonstrate that USP21 mediates the deubiquitination of multiple well-known target proteins associated with critical cellular processes relevant to both disease and homeostasis, particularly in various cancers.This reviewcomprehensively summarizes the structure and biological functions of USP21 with an emphasis on its role in tumorigenesis, and elucidates the advances on the discovery of tens of small-molecule inhibitors targeting USP21, which suggests that targeting USP21 may represent a potential strategy for cancer therapy.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Animals
Enzyme Inhibitors pharmacology
Enzyme Inhibitors chemistry
Molecular Structure
Neoplasms drug therapy
Neoplasms pathology
Neoplasms metabolism
Ubiquitin Thiolesterase antagonists & inhibitors
Ubiquitin Thiolesterase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 147
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38688196
- Full Text :
- https://doi.org/10.1016/j.bioorg.2024.107400