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Possible vertical transmission of Chikungunya virus infection detected in the cord blood samples from a birth cohort in Vietnam.
- Source :
-
Journal of infection and public health [J Infect Public Health] 2024 Jun; Vol. 17 (6), pp. 1050-1056. Date of Electronic Publication: 2024 Apr 21. - Publication Year :
- 2024
-
Abstract
- Background: Chikungunya virus (CHIKV) is an alphavirus (genus Alphavirus, family Togaviridae) that is primarily transmitted to humans by Aedes mosquitoes, and can be transmitted from mother to child. Little is known about CHIKV transmission in Vietnam, where dengue is endemic and Aedes mosquitoes are abundant. This study aimed to determine the prevalence and characteristics of vertical CHIKV infection in a birth cohort, and seroprevalence of anti-CHIKV antibodies with or without confirmation by neutralization tests among women bearing children in Vietnam.<br />Methods: We collected umbilical cord blood plasma samples from each newly delivered baby in Nha Trang, Central Vietnam, between July 2017 and September 2018. Samples were subjected to molecular assay (quantitative real-time RT-PCR) and serological tests (anti-CHIKV IgM capture and IgG indirect enzyme-linked immunosorbent assay, and neutralization tests).<br />Results: Of the 2012 tested cord blood samples from newly delivered babies, the CHIKV viral genome was detected in 6 (0.3%) samples by RT-PCR, whereas, 15 samples (0.7%) were anti-CHIKV-IgM positive. Overall, 18 (0.9%, 95% CI: 0.6-1.5) samples, including three positives for both CHIKV IgM and viral genome on RT-PCR, were regarded as vertical transmission of CHIKV infection. Of the 2012 cord blood samples, 10 (0.5%, 95% CI: 0.2-0.9) were positive for both anti-CHIKV IgM and IgG. Twenty-nine (1.4%, 95% CI: 1.0-2.1) were seropositive for anti-CHIKV IgG while 26 (1.3%, 95% CI: 0.8-1.9) of them were also positive for neutralizing antibodies, and regarded as seropositive with neutralization against CHIKV infection.<br />Conclusion: This is the first report of a possible CHIKV maternal-neonatal infection in a birth cohort in Vietnam. The findings indicate that follow-up and a differential diagnosis of CHIKV infection in pregnant women are needed to clarify the potential for CHIKV vertical transmission and its impact in the newborn.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Vietnam epidemiology
Female
Adult
Seroepidemiologic Studies
Infant, Newborn
Pregnancy
Birth Cohort
Male
Prevalence
Young Adult
Antibodies, Neutralizing blood
Enzyme-Linked Immunosorbent Assay
Neutralization Tests
Fetal Blood virology
Infectious Disease Transmission, Vertical statistics & numerical data
Antibodies, Viral blood
Chikungunya Fever transmission
Chikungunya Fever epidemiology
Chikungunya virus isolation & purification
Chikungunya virus immunology
Chikungunya virus genetics
Immunoglobulin M blood
Immunoglobulin G blood
Subjects
Details
- Language :
- English
- ISSN :
- 1876-035X
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of infection and public health
- Publication Type :
- Academic Journal
- Accession number :
- 38688178
- Full Text :
- https://doi.org/10.1016/j.jiph.2024.04.012