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Impact of Using Pre- and Post-Bronchodilator Spirometry Reference Values in a Chinese Population.
- Source :
-
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Apr 30. Date of Electronic Publication: 2024 Apr 30. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Rationale: Spirometry reference equations that are derived from a large, nationally representative, general population are warranted in China and the impact of using pre- and post-BD spirometry reference values has yet to be assessed in Chinese populations.<br />Objectives: To present both the pre-BD and post-BD spirometry reference values for Chinese adults using the China Pulmonary Health (CPH) study.<br />Methods: A reference population of 17969 healthy, non-smoking participants in the CPH study was used to calculate the pre- and post-BD reference values for the forced expiratory volume in 1 s (FEV <subscript>1</subscript> ), forced vital capacity (FVC) and FEV <subscript>1</subscript> /FVC. Both pre- and post-BD reference values were applied to the entire CPH population (50991 individuals) to illustrate the divergence between the use of references in determining the disease prevalence and severity grading.<br />Measurements and Main Results: The prevalence of airflow limitation was 5.36% using pre-BD reference and 8.02% using the post-BD reference. Individuals who had post-BD FEV <subscript>1</subscript> /FVC below post-BD but higher than pre-BD reference values were found to have significantly higher rates of self-reported respiratory symptoms, and significantly lower values in spirometry indicators than those above post-BD reference values. An additional 3.51% of participants were identified as grade II-IV COPD using the post-BD FEV <subscript>1</subscript> predicted values.<br />Conclusion: This study generated and applied pre- and post-bronchodilator spirometry reference values in a nationally representative Chinese adult population. Post-BD reference values may serve as an additional criterion in identifying individuals at risk for obstructive pulmonary diseases, its diagnostic and prognostic values should be further investigated.
Details
- Language :
- English
- ISSN :
- 1535-4970
- Database :
- MEDLINE
- Journal :
- American journal of respiratory and critical care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38687500
- Full Text :
- https://doi.org/10.1164/rccm.202308-1488OC