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Prognostic utility of blood inflammation biomarkers before and after treatment on the survival of patients with locally advanced non-small cell lung cancer undergoing stereotactic body radiotherapy.
- Source :
-
The clinical respiratory journal [Clin Respir J] 2024 May; Vol. 18 (5), pp. e13749. - Publication Year :
- 2024
-
Abstract
- Background and Objective: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were significant and succinct indicators of systemic inflammation. We assessed the influence of stereotactic body radiotherapy (SBRT) on NLR and PLR in patients with locally advanced non-small cell lung cancer (LA-NSCLC).<br />Methods: We reviewed the medical data of patients with LA-NSCLC who underwent SBRT between 1 January 2013 and 31 December 2018. NLR and PLR values recorded at pre- and post-SBRT were examined. We assessed the correlation between pre/post-SBRT NLR and PLR and survival outcomes. The decision tree evaluation was conducted using Chi-square automatic detection.<br />Results: In total, 213 patients were included in the study with a median follow-up duration of 40.00 (ranging from 5.28 to 100.70) months. Upon dichotomization by a median, we identified that post-SBRT NLR > 5.5 and post-SBRT PLR > 382.0 were negatively associated with shorter overall survival (OS). In the multivariate assessment, post-SBRT PLR > 382.0 was the only factor. Based on post-SBRT PLR, tumor locations, and tumor stage, we categorized patients into low, medium, or high-risk groups.<br />Conclusions: Post-SBRT PLR > 382.0 correlated with survival in patients undergoing SBRT. The decision tree model might play a role in future risk stratification to guide the clinical practice of individualized SBRT for LA-NSCLC.<br /> (© 2024 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Male
Female
Aged
Prognosis
Middle Aged
Retrospective Studies
Lymphocytes pathology
Aged, 80 and over
Blood Platelets pathology
Lymphocyte Count
Platelet Count
Survival Rate trends
Neoplasm Staging
Biomarkers, Tumor blood
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung radiotherapy
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung surgery
Lung Neoplasms pathology
Lung Neoplasms mortality
Lung Neoplasms blood
Lung Neoplasms radiotherapy
Lung Neoplasms surgery
Radiosurgery methods
Neutrophils pathology
Inflammation blood
Subjects
Details
- Language :
- English
- ISSN :
- 1752-699X
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The clinical respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 38685745
- Full Text :
- https://doi.org/10.1111/crj.13749