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Vocal and tongue exercise in early to mid-stage Parkinson disease using the Pink1-/- rat.

Authors :
Hoffmeister JD
Broadfoot CK
Schaen-Heacock NE
Lechner SA
Krasko MN
Nisbet AF
Russell J
Szot J
Glass TJ
Connor NP
Kelm-Nelson CA
Ciucci MR
Source :
Brain research [Brain Res] 2024 Aug 15; Vol. 1837, pp. 148958. Date of Electronic Publication: 2024 Apr 27.
Publication Year :
2024

Abstract

Vocal and swallowing deficits are common in Parkinson disease (PD). Because these impairments are resistant to dopamine replacement therapies, vocal and lingual exercise are the primary treatment, but not all individuals respond to exercise and neural mechanisms of treatment response are unclear. To explore putative mechanisms, we used the progressive Pink1-/- rat model of early to mid-stage PD and employed vocal and lingual exercises at 6- and 10-months of age in male Pink1-/- and wild type (WT) rats. We hypothesized that vocal and lingual exercise would improve vocal and tongue use dynamics and increase serotonin (5HT) immunoreactivity in related brainstem nuclei. Rats were tested at baseline and after 8 weeks of exercise or sham exercise. At early-stage PD (6 months), vocal exercise resulted in increased call complexity, but did not change intensity, while at mid-stage (10 months), vocal exercise no longer influenced vocalization complexity. Lingual exercise increased tongue force generation and reduced relative optical density of 5HT in the hypoglossal nucleus at both time points. The effects of vocal and lingual exercise at these time points are less robust than in prodromal stages observed in previous work, suggesting that early exercise interventions may yield greater benefit. Future work targeting optimization of exercise at later time points may facilitate clinical translation.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-6240
Volume :
1837
Database :
MEDLINE
Journal :
Brain research
Publication Type :
Academic Journal
Accession number :
38685371
Full Text :
https://doi.org/10.1016/j.brainres.2024.148958