Back to Search Start Over

Apoptosis of Dendritic Cells and Autoimmune Disease.

Authors :
Sun L
Ding F
Zhou L
Wang J
Li M
Zhou P
Li J
Ding C
Wang H
Xu Y
Source :
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Apr 22; Vol. 29 (4), pp. 157.
Publication Year :
2024

Abstract

Dendritic cells (DCs), the most efficient antigen-presenting cells (APCs), bridge the innate and adaptive immune systems. As such, the turn-over of DCs is critical during autoimmune responses, and the dysregulation of DC apoptosis could cause severe immune destruction in the host. For example, reduction of immunogenic DCs by increased apoptosis could lead to immune tolerance to pathogen infection that might allow exposure of nuclear autoantigens, whereas reduced apoptosis could result in long-term lymphocyte activation to break the immune tolerance for the development of autoimmune disease. Thus, keeping a balance between survival and apoptosis of DCs is crucial to maintain immune homeostasis. In this review, we summarize the recent development on the factors inducing DC apoptosis and their underlying mechanisms to provide insights into the immunopathogenesis of some autoimmune diseases, which could lead to effective therapeutic interventions in the clinics.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2024 The Author(s). Published by IMR Press.)

Details

Language :
English
ISSN :
2768-6698
Volume :
29
Issue :
4
Database :
MEDLINE
Journal :
Frontiers in bioscience (Landmark edition)
Publication Type :
Academic Journal
Accession number :
38682203
Full Text :
https://doi.org/10.31083/j.fbl2904157