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Phosphine-Catalyzed (4 + 2) Annulation of Allenoates Bearing Acidic Hydrogen with 1,1-Dicyanoalkenes.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2024 May 17; Vol. 89 (10), pp. 7169-7174. Date of Electronic Publication: 2024 Apr 28. - Publication Year :
- 2024
-
Abstract
- α-succinimide-substituted allenoates were employed as phosphine acceptors in phosphine-catalyzed (4 + 2) annulation with 1,1-dicyanoalkenes. They served as C4 synthons in the annulation reaction under mild reaction conditions and produced hexahydroisoindole derivatives in moderate to high yields with good to excellent diastereoselectivities.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 89
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38679873
- Full Text :
- https://doi.org/10.1021/acs.joc.4c00564