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Cutibacterium acnes in spine surgery: pathophysiology, diagnosis, and treatment.
- Source :
-
The spine journal : official journal of the North American Spine Society [Spine J] 2024 Sep; Vol. 24 (9), pp. 1545-1552. Date of Electronic Publication: 2024 Apr 26. - Publication Year :
- 2024
-
Abstract
- Cutibacterium acnes (C. acnes) previously named Propionibacterium acnes (P. acnes) has been increasingly recognized by spine surgeons as a cause of indolent postsurgical spinal infection. Patients infected with C. acnes may present with pseudarthrosis or nonspecific back pain. Currently, microbiological tissue cultures remain the gold standard in diagnosing C. acnes infection. Ongoing research into using genetic sequencing as a diagnostic method shows promising results and may be another future way of diagnosis. Optimized prophylaxis involves the use of targeted antibiotics, longer duration of antibiotic prophylaxis, antibacterial-coated spinal implants, and evidence-based sterile surgical techniques all of which decrease contamination. Antibiotics and implant replacement remain the mainstay of treatment, with longer durations of antibiotics proving to be more efficacious. Local guidelines must consider the surge of antimicrobial resistance worldwide when treating C. acnes.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Spine surgery
Propionibacterium acnes isolation & purification
Gram-Positive Bacterial Infections diagnosis
Gram-Positive Bacterial Infections drug therapy
Gram-Positive Bacterial Infections microbiology
Gram-Positive Bacterial Infections therapy
Anti-Bacterial Agents therapeutic use
Surgical Wound Infection microbiology
Surgical Wound Infection diagnosis
Surgical Wound Infection therapy
Surgical Wound Infection drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1632
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The spine journal : official journal of the North American Spine Society
- Publication Type :
- Academic Journal
- Accession number :
- 38679079
- Full Text :
- https://doi.org/10.1016/j.spinee.2024.04.018