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Salvage Radiotherapy PSMA PET/CT-guided in Men With PSA Recurrence.
- Source :
-
Anticancer research [Anticancer Res] 2024 May; Vol. 44 (5), pp. 2205-2210. - Publication Year :
- 2024
-
Abstract
- Background/aim: To evaluate the clinical outcome in men with recurrent prostate cancer (PCa) treated by salvage radiotherapy (sRT) prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT)-guided.<br />Patients and Methods: From January 2021 to January 2023, 33 patients who previously underwent definitive/systemic therapy were submitted to sRT PSMA PET/CT-guided for PCa recurrence: 16 (48.5%) on the prostate bed (PB), 12 (36.4%) on the lymph node (LN) and five (15.1%) on the bone. The median PSA value was 3.3 ng/ml (range=0.3-15.5 ng/ml): 0.2-0.5 ng/ml (18.2% cases), 0.51-1 ng/ml (39.4% cases) and >1 ng/ml (42.4% cases). Median <superscript>18</superscript> F PSMA PET/CT standardized uptake value (SUVmax) was evaluated on PB, vs. LN vs. bones PCa recurrences and was equal to 12.5 vs. 19.0 vs. 30.1, respectively.<br />Results: Overall, at a median follow up of 12 months, 23/33 patients (69.7%) had local control without distant progression (PSA and SUVmax evaluation): 14/16 (87.5%) vs. 7/12 (58.3%) vs. 2/5 (40%) underwent sRT on the PB vs. LN vs. bone metastases, respectively.<br />Conclusion: PSMA PET/CT allows to perform sRT early in men with PCa recurrence and low PSA values obtaining a complete clinical response in approximately 70% of the cases one year from treatment.<br /> (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Humans
Male
Aged
Middle Aged
Aged, 80 and over
Glutamate Carboxypeptidase II metabolism
Antigens, Surface
Radiotherapy, Image-Guided methods
Positron Emission Tomography Computed Tomography methods
Prostatic Neoplasms radiotherapy
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms pathology
Prostatic Neoplasms blood
Prostate-Specific Antigen blood
Neoplasm Recurrence, Local radiotherapy
Neoplasm Recurrence, Local diagnostic imaging
Neoplasm Recurrence, Local pathology
Salvage Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 38677723
- Full Text :
- https://doi.org/10.21873/anticanres.17027