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Cortical and subcortical functional connectivity and cognitive impairment in Parkinson's disease.
Cortical and subcortical functional connectivity and cognitive impairment in Parkinson's disease.
- Source :
-
NeuroImage. Clinical [Neuroimage Clin] 2024; Vol. 42, pp. 103610. Date of Electronic Publication: 2024 Apr 25. - Publication Year :
- 2024
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Abstract
- Parkinson's disease (PD) is a neurodegenerative disease with cognitive as well as motor impairments. While much is known about the brain networks leading to motor impairments in PD, less is known about the brain networks contributing to cognitive impairments. Here, we leveraged resting-state functional magnetic resonance imaging (rs-fMRI) data from the Parkinson's Progression Marker Initiative (PPMI) to examine network dysfunction in PD patients with cognitive impairment. We focus on canonical cortical networks linked to cognition, including the salience network (SAL), frontoparietal network (FPN), and default mode network (DMN), as well as a subcortical basal ganglia network (BGN). We used the Montreal Cognitive Assessment (MoCA) as a continuous index of coarse cognitive function in PD. In 82 PD patients, we found that lower MoCA scores were linked with lower intra-network connectivity of the FPN. We also found that lower MoCA scores were linked with lower inter-network connectivity between the SAL and the BGN, the SAL and the DMN, as well as the FPN and the DMN. These data elucidate the relationship of cortical and subcortical functional connectivity with cognitive impairments in PD.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Cerebral Cortex physiopathology
Cerebral Cortex diagnostic imaging
Connectome methods
Brain physiopathology
Brain diagnostic imaging
Default Mode Network physiopathology
Default Mode Network diagnostic imaging
Parkinson Disease physiopathology
Parkinson Disease diagnostic imaging
Parkinson Disease complications
Cognitive Dysfunction physiopathology
Cognitive Dysfunction etiology
Cognitive Dysfunction diagnostic imaging
Magnetic Resonance Imaging methods
Nerve Net physiopathology
Nerve Net diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2213-1582
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- NeuroImage. Clinical
- Publication Type :
- Academic Journal
- Accession number :
- 38677099
- Full Text :
- https://doi.org/10.1016/j.nicl.2024.103610