Back to Search
Start Over
Differential Effects of n -3 and n -6 Polyunsaturated Fatty Acids on Placental and Embryonic Growth and Development in Diabetic Pregnant Mice.
- Source :
-
Nutrients [Nutrients] 2024 Apr 16; Vol. 16 (8). Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- The present study aimed to investigate the differential effects of n -3 and n -6 polyunsaturated fatty acids (PUFAs) on placental and embryonic development. Pregnant mice were assigned to five groups: healthy control (HC), diabetes mellitus control (DMC), diabetes + low-dose n -3 PUFA (L n -3), diabetes + high-dose n -3 PUFA (H n -3), and diabetes + n -6 PUFA ( n -6). On E12.5d, the H n -3 group, but not the n -6 group, had a higher placenta weight. The weight ratio of embryo to placenta in the n -6 group was significantly lower than in the H n -3 group but higher than in the DMC group. The H n -3 group had significantly higher protein levels of VEGF, IGF-1, and IGFBP3, while the n -6 group had lower VEGF than the DMC group. Compared with the DMC group, embryonic Cer-16:0 was significantly higher in the H n -3 group, while embryonic PC (36:6), PC (38:7), and PE (40:7) were significantly lower in the n -6 group. The embryo and placenta weights were positively correlated with placental VEGF, IGFBP3, and embryonic Cer-16:0, and they were negatively correlated with embryonic PC (36:6) and PE (40:7). The weight ratio of embryo to placenta was negatively correlated with embryonic PC (36:6). In addition, embryonic Cer-16:0 was positively correlated with placental VEGF and IGFBP3. In conclusion, n -3 PUFA and n -6 PUFA improved placental and embryonic growth through different mechanisms.
- Subjects :
- Animals
Pregnancy
Female
Mice
Diabetes Mellitus, Experimental
Insulin-Like Growth Factor Binding Protein 3 metabolism
Vascular Endothelial Growth Factor A metabolism
Pregnancy in Diabetics metabolism
Insulin-Like Growth Factor I metabolism
Organ Size drug effects
Fatty Acids, Omega-3 pharmacology
Placenta metabolism
Placenta drug effects
Fatty Acids, Omega-6 pharmacology
Embryonic Development drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 38674874
- Full Text :
- https://doi.org/10.3390/nu16081182