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Association between Homocysteine and Vitamin D Levels in Asymptomatic Korean Adults.
- Source :
-
Nutrients [Nutrients] 2024 Apr 13; Vol. 16 (8). Date of Electronic Publication: 2024 Apr 13. - Publication Year :
- 2024
-
Abstract
- An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease. In addition, vitamin D deficiency is associated with coronary artery disease and metabolic disorders. The present study included data from 1375 adults (895 men and 480 women) with a mean age of 52.62 ± 9.94 years who visited the Health Promotion Center of the University Hospital in Gyeonggi-do, Republic of Korea from January 2018 to December 2022 for routine checkups that included assessments of their homocysteine and vitamin D levels. Homocysteine levels were positively associated with age, a history of hypertension, a history of diabetes, current smoking habits, and levels of low-density lipoprotein cholesterol, creatinine, uric acid, and high-sensitivity C-reactive protein. By contrast, vitamin D levels were negatively associated with serum levels of homocysteine after adjusting for covariates ( β = -0.033, p < 0.001). Additional long-term prospective studies are needed to elucidate the presence of a causal relationship between vitamin D status and serum levels of homocysteine in asymptomatic Korean adults. An intervention trial is warranted to determine whether the administration of vitamin D is helpful for the primary prevention of cardiovascular disease by lowering the homocysteine level in this population.
- Subjects :
- Humans
Female
Male
Republic of Korea epidemiology
Middle Aged
Adult
Risk Factors
Vitamin D Deficiency blood
Vitamin D Deficiency epidemiology
Cross-Sectional Studies
Aged
Cardiovascular Diseases epidemiology
Cardiovascular Diseases prevention & control
Cardiovascular Diseases blood
Cardiovascular Diseases etiology
Homocysteine blood
Vitamin D blood
Vitamin D analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 38674846
- Full Text :
- https://doi.org/10.3390/nu16081155