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Comparative Analysis of Olive-Derived Phenolic Compounds' Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 19; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 19. - Publication Year :
- 2024
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Abstract
- Olive leaf contains plenty of phenolic compounds, among which oleuropein (OP) is the main component and belongs to the group of secoiridoids. Additionally, phenolic compounds such as oleocanthal (OL) and oleacein (OC), which share a structural similarity with OP and two aldehyde groups, are also present in olive leaves. These compounds have been studied for several health benefits, such as anti-cancer and antioxidant effects. However, their impact on the skin remains unknown. Therefore, this study aims to compare the effects of these three compounds on melanogenesis using B16F10 cells and human epidermal cells. Thousands of gene expressions were measured by global gene expression profiling with B16F10 cells. We found that glutaraldehyde compounds derived from olive leaves have a potential effect on the activation of the melanogenesis pathway and inducing differentiation in B16F10 cells. Accordingly, the pro-melanogenesis effect was investigated by means of melanin quantification, mRNA, and protein expression using human epidermal melanocytes (HEM). This study suggests that secoiridoid and its derivates have an impact on skin protection by promoting melanin production in both human and mouse cell lines.
- Subjects :
- Humans
Animals
Mice
Iridoids pharmacology
Aldehydes pharmacology
Cell Differentiation drug effects
Cyclopentane Monoterpenes
Epidermal Cells metabolism
Epidermal Cells drug effects
Plant Extracts pharmacology
Plant Extracts chemistry
Epidermis metabolism
Epidermis drug effects
Cell Line, Tumor
Plant Leaves chemistry
Melanoma, Experimental metabolism
Melanoma, Experimental pathology
Melanogenesis
Melanocytes drug effects
Melanocytes metabolism
Olea chemistry
Melanins biosynthesis
Melanins metabolism
Phenols pharmacology
Iridoid Glucosides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38674064
- Full Text :
- https://doi.org/10.3390/ijms25084479