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Mitigating effect of pomegranate peel extract against the furan induced testicular injury by apoptosis, steroidogenic enzymes and oxidative stress.
- Source :
-
Chemosphere [Chemosphere] 2024 Jun; Vol. 358, pp. 142086. Date of Electronic Publication: 2024 Apr 24. - Publication Year :
- 2024
-
Abstract
- Furan is generated in a wide array of heat-treated foods through thermal degradation, leading to severe impairments in the male reproductive system. The main objective of this study was to investigate the potential of pomegranate peel extract (PGPE) in mitigating testicular dysfunctions induced by furan. Male rats were categorized into four groups: control/untreated, PGPE, furan, and PGPE + furan group. The study results revealed that furan-treated rats exhibited significantly elevated aminotransferase and phosphatase activity, and also generated increased oxidative stress, and reduced antioxidative stress protein activity. Additionally, protein content levels (ALT, AST, ALP, and ACP) and activities of steroidogenic Leydig cell hydroxysteroid dehydrogenase (3β-HSD and 17β-HSD) enzymes were significantly decreased. Significant variations in testicular parameters, apoptotic genes (Bcl-2, P53, and Caspase3), inflammatory and anti-inflammatory cytokines (IL1β, IL10), male sex hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and sperm quality were also observed. Furthermore, testicular histological abnormalities were confirmed by biochemical and molecular modifications. Notably, PGPE pre-treated furan-intoxicated animals exhibited significant improvements in most of the assessed parameters compared to furan-treated groups. In conclusion, PGPE presents essential preventive measures and a novel pharmacological potential therapy against furan-induced testicular injury.<br />Competing Interests: Declaration of competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Male
Animals
Rats
Testosterone metabolism
Luteinizing Hormone
17-Hydroxysteroid Dehydrogenases metabolism
Follicle Stimulating Hormone
Leydig Cells drug effects
Leydig Cells metabolism
Antioxidants metabolism
Oxidative Stress drug effects
Testis drug effects
Testis metabolism
Testis pathology
Plant Extracts pharmacology
Plant Extracts chemistry
Apoptosis drug effects
Pomegranate chemistry
Furans pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1298
- Volume :
- 358
- Database :
- MEDLINE
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 38670510
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2024.142086