Mitochondrial sites of contact with the nucleus.

Authors :: Campanella M
Kannan B
Source :: The Journal of cell biology [J Cell Biol] 2024 Jun 03; Vol. 223 (6). Date of Electronic Publication: 2024 Apr 26.
Publication Year :: 2024
Abstract: Membrane contact sites (MCS) between mitochondria and the nucleus have been recently described. Termed nucleus associated mitochondria (NAM), they prime the expression of genes required for cellular resistance to stressors, thus offering a tethering mechanism for homeostatic communication. Here, we discuss the composition of NAM and their physiological and pathological significance.<br /> (© 2024 Campanella and Kannan.)