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Usnic Acid Targets 14-3-3 Proteins and Suppresses Cancer Progression by Blocking Substrate Interaction.
- Source :
-
JACS Au [JACS Au] 2024 Apr 11; Vol. 4 (4), pp. 1521-1537. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- The anticancer therapeutic effects of usnic acid (UA), a lichen secondary metabolite, have been demonstrated in vitro and in vivo . However, the mechanism underlying the anticancer effect of UA remains to be clarified. In this study, the target protein of UA was identified using a UA-linker-Affi-Gel molecule, which showed that UA binds to the 14-3-3 protein. UA binds to 14-3-3, causing the degradation of proteasomal and autophagosomal proteins. The interaction of UA with 14-3-3 isoforms modulated cell invasion, cell cycle progression, aerobic glycolysis, mitochondrial biogenesis, and the Akt/mTOR, JNK, STAT3, NF-κB, and AP-1 signaling pathways in colorectal cancer. A peptide inhibitor of 14-3-3 blocked or regressed the activity of UA and inhibited its effects. The results suggest that UA binds to 14-3-3 isoforms and suppresses cancer progression by affecting 14-3-3 targets and phosphorylated proteins.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2024 The Authors. Published by American Chemical Society.)
Details
- Language :
- English
- ISSN :
- 2691-3704
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- JACS Au
- Publication Type :
- Academic Journal
- Accession number :
- 38665668
- Full Text :
- https://doi.org/10.1021/jacsau.3c00774