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Changes in bacterial community composition in the uterus of Holstein cow with endometritis before and after treatment with oxytetracycline.
- Source :
-
Scientific reports [Sci Rep] 2024 Apr 25; Vol. 14 (1), pp. 9511. Date of Electronic Publication: 2024 Apr 25. - Publication Year :
- 2024
-
Abstract
- It is important to study the bacteria that cause endometritis to identify effective therapeutic drugs for dairy cows. In this study, 20% oxytetracycline was used to treat Holstein cows (nā=ā6) with severe endometritis. Additional 10 Holstein cows (5 for healthy cows, 5 for cows with mild endometritis) were also selected. At the same time, changes in bacterial communities were monitored by high-throughput sequencing. The results show that Escherichia coli, Staphylococcus aureus and other common pathogenic bacteria could be detected by traditional methods in cows both with and without endometritis. However, 16S sequencing results show that changes in the abundance of these bacteria were not significant. Endometritis is often caused by mixed infections in the uterus. Oxytetracycline did not completely remove existing bacteria. However, oxytetracycline could effectively inhibit endometritis and had a significant inhibitory effect on the genera Bacteroides, Trueperella, Peptoniphilus, Parvimonas, Porphyromonas, and Fusobacterium but had no significant inhibitory effect on the bacterial genera Marinospirillum, Erysipelothrix, and Enteractinococcus. During oxytetracycline treatment, the cell motility, endocrine system, exogenous system, glycan biosynthesis and metabolism, lipid metabolism, metabolism of terpenoids, polyketides, cofactors and vitamins, signal transduction, and transport and catabolism pathways were affected.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Female
Cattle
Bacteria drug effects
Bacteria classification
Bacteria genetics
Bacteria isolation & purification
Cattle Diseases microbiology
Cattle Diseases drug therapy
RNA, Ribosomal, 16S genetics
Microbiota drug effects
Oxytetracycline pharmacology
Oxytetracycline therapeutic use
Endometritis microbiology
Endometritis veterinary
Endometritis drug therapy
Uterus microbiology
Uterus drug effects
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38664449
- Full Text :
- https://doi.org/10.1038/s41598-024-59674-4