Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders.

Authors :: Mathias K
Machado RS
Stork S
Martins CD
da Silva Kursancew AC
de Rezende VL
Gonçalves CL
Barichello T
Prophiro JS
Petronilho F
Source :: Inflammation [Inflammation] 2024 Apr 26. Date of Electronic Publication: 2024 Apr 26.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: The Bacille Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines in the world for the prevention of tuberculosis. Its immunological capacity also includes epigenetic reprogramming, activation of T cells and inflammatory responses. Although the main usage of the vaccine is the prevention of tuberculosis, different works have shown that the effect of BCG can go beyond the peripheral immune response and be linked to the central nervous system by modulating the immune system at the level of the brain. This review therefore aims to describe the BCG vaccine, its origin, its relationship with the immune system, and its involvement at the brain level.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)