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Single versus multiple reoperations for recurrent intracranial meningiomas.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2024 Jul; Vol. 168 (3), pp. 527-535. Date of Electronic Publication: 2024 Apr 24. - Publication Year :
- 2024
-
Abstract
- Purpose: To identify the risk factors and management of the multiple recurrences and reoperations for intracranial meningiomas.<br />Methods: Data of a neurosurgical series of 35 patients reoperated on for recurrent intracranial meningiomas were reviewed. Analyzed factors include patient age and sex, tumor location, extent of resection, WHO grade, Ki67-MIB1 and PR expression at initial diagnosis, time to recurrence; pattern of regrowth, extent of resection, WHO grade and Ki67-MIB1 at first recurrence were also analyzed. All these factors were stratified into two groups based on single (Group A) and multiple reoperations (Group B).<br />Results: Twenty-four patients (69%) belonged to group A and 11 (31%) to group B. The age < 65 years, male sex, incomplete resection at both initial surgery and first reoperation, and multicentric-diffuse pattern of regrowth at first recurrence are risk factors for multiple recurrences and reoperations. In group B, the WHO grade and Ki67-MIB1 increased in further recurrences in 54% and 64%, respectively. The time to recurrence was short in 7 cases (64%), whereas 4 patients (36%) further recurred after many years. Eight patients (73%) are still alive after 7 to 22 years and 2 to 4 reoperations.<br />Conclusion: The extent of resection and the multicentric-diffuse pattern of regrowth at first recurrence are the main risk factors for multiple recurrences and reoperations. Repeated reoperations might be considered even in patients with extensive recurrent tumors before the anaplastic transformation occurs. In such cases, even partial tumor resections followed by radiation therapy may allow long survival in good clinical conditions.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Aged
Ki-67 Antigen metabolism
Risk Factors
Retrospective Studies
Follow-Up Studies
Young Adult
Meningioma surgery
Meningioma pathology
Reoperation statistics & numerical data
Neoplasm Recurrence, Local surgery
Neoplasm Recurrence, Local pathology
Meningeal Neoplasms surgery
Meningeal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 168
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38656725
- Full Text :
- https://doi.org/10.1007/s11060-024-04673-8