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Cardiovascular Health, Race, and Decline in Cognitive Function in Midlife Women: The Study of Women's Health Across the Nation.
- Source :
-
Journal of the American Heart Association [J Am Heart Assoc] 2024 May 07; Vol. 13 (9), pp. e031619. Date of Electronic Publication: 2024 Apr 24. - Publication Year :
- 2024
-
Abstract
- Background: Cognitive decline may progress for decades before dementia onset. Better cardiovascular health (CVH) has been related to less cognitive decline, but it is unclear whether this begins early, for all racial subgroups, and all domains of cognitive function. The purpose of this study was to determine the impact of CVH on decline in the 2 domains of cognition that decline first in White and Black women at midlife.<br />Methods and Results: Subjects were 363 Black and 402 White women, similar in baseline age (mean±SD, 46.6±3.0 years) and education (15.7±2.0 years), from the Chicago site of the Study of Women's Health Across the Nation. Cognition, measured as processing speed and working memory, was assessed annually or biennially over a maximum of 20 years (mean±SD, 9.8±6.7 years). CVH was measured as Life's Essential 8 (blood pressure, body mass index, glucose, non-high-density lipoprotein cholesterol, smoking, physical activity, diet, sleep). Hierarchical linear mixed models identified predictors of cognitive decline with progressive levels of adjustment. There was a decline in processing speed that was explained by race, age, and the 3-way interaction of race, CVH, and time ( F <subscript>1,4308</subscript> =8.8, P =0.003). CVH was unrelated to decline in White women but in Black women poorer CVH was associated with greater decline. Working memory did not decline in the total cohort, by race, or by CVH.<br />Conclusions: In midlife Black women, CVH promotion may be a target for preventing the beginnings of cognitive decline, thereby enhancing independent living with aging.
- Subjects :
- Adult
Female
Humans
Middle Aged
Age Factors
Cardiovascular Diseases ethnology
Cardiovascular Diseases epidemiology
Cardiovascular Diseases psychology
Chicago epidemiology
Cognitive Aging psychology
Heart Disease Risk Factors
Risk Factors
United States epidemiology
White
Black or African American psychology
Cognition physiology
Cognitive Dysfunction epidemiology
Cognitive Dysfunction ethnology
Cognitive Dysfunction physiopathology
Cognitive Dysfunction diagnosis
Memory, Short-Term physiology
White People statistics & numerical data
Women's Health ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 2047-9980
- Volume :
- 13
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Heart Association
- Publication Type :
- Academic Journal
- Accession number :
- 38656121
- Full Text :
- https://doi.org/10.1161/JAHA.123.031619