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Negative Pressure Wound Therapy to Reduce Surgical Site Infections after CRS/HIPEC.
- Source :
-
Annals of surgical oncology [Ann Surg Oncol] 2024 Jul; Vol. 31 (7), pp. 4735-4740. Date of Electronic Publication: 2024 Apr 23. - Publication Year :
- 2024
-
Abstract
- Background: Surgical site infections (SSIs) are a common cause of morbidity after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Negative pressure wound therapy (NPWT) has been proposed as a method to reduce the rates of SSIs; however, there is paucity in the literature on the efficacy in this population. The goal of this study was to determine whether routine use of NPWT in patients undergoing CRS/HIPEC could reduce the risk of developing SSI.<br />Methods: We performed a retrospective before-after study to assess the rates of SSI with NPWT compared with a standard postoperative surgical dressing (SSD) in all patients undergoing CRS/HIPEC from November 2013 to December 2021 at a single tertiary care center. The primary outcome was rate of SSI. A multivariate logistic regression analysis was performed to evaluate for risk factors for SSI.<br />Results: A total of 178 patients were treated with CRS/HIPEC over the study period. Seventy patients had placement of SSD, and 108 patients had placement of NPWT. Rates of SSI were 11.4% (8/70) and 5.6% (6/108) in the two groups, respectively (p = 0.16). On multivariate analysis, patients treated with NPWT had a significantly lower risk of developing an SSI (OR 0.24 [0.06, 0.92], p = 0.037). Patients living >50 km from the hospital had significantly higher risk of developing SSI (OR 2.03 [1.09, 3.78], p = 0.026).<br />Conclusions: These results suggest that routine use of NPWT can reduce the risk of developing an SSI in patients undergoing CRS/HIPEC for peritoneal malignancy.<br /> (© 2024. Society of Surgical Oncology.)
- Subjects :
- Humans
Female
Male
Retrospective Studies
Middle Aged
Follow-Up Studies
Prognosis
Combined Modality Therapy
Aged
Risk Factors
Surgical Wound Infection prevention & control
Surgical Wound Infection etiology
Negative-Pressure Wound Therapy methods
Cytoreduction Surgical Procedures adverse effects
Hyperthermic Intraperitoneal Chemotherapy adverse effects
Peritoneal Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4681
- Volume :
- 31
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Annals of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38653941
- Full Text :
- https://doi.org/10.1245/s10434-024-15283-z