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Gastrointestinal response to the early administration of antimicrobial agents in growing turkeys infected with Escherichia coli.
- Source :
-
Poultry science [Poult Sci] 2024 Jun; Vol. 103 (6), pp. 103720. Date of Electronic Publication: 2024 Apr 03. - Publication Year :
- 2024
-
Abstract
- This study investigated the effects of the early administration of enrofloxacin (E) or doxycycline (D) for the first 5 consecutive days of life, or the continuous administration of the coccidiostat monensin (M) throughout the rearing period on gastrointestinal function in turkeys infected with avian pathogenic Escherichia coli (APEC) in an early or later stage of rearing. Experiment 1 lasted 21 d, and turkeys in groups E, D, and M were infected with APEC on d 15. Experiment 2 lasted 56 d, and it had a factorial arrangement of treatments where birds in groups E, D, and M were infected with APEC on d 15 or d 50. In both experiments, control groups (C) consisted of infected and uninfected birds without antibiotic or coccidiostat administration. On d 21 (Experiment 1) and d 56 (Experiment 2), 8 birds from each subgroup were killed, and the ileal and cecal digesta were sampled to analyze the activity of bacterial enzymes and the concentrations of short-chain fatty acids (SCFA). The experimental treatments did not affect the final body weight or body weight gain of birds. Both experiments demonstrated that APEC contributed to an increase in ammonia levels of the cecal digesta (means from 2 experiments: 0.311 vs. 0.225 mg/g in uninfected birds) and ileal pH (6.79 vs. 6.00) and viscosity (2.43 vs. 1.83 mPa⋅s). Moreover, the E. coli challenge enhanced the extracellular activity of several cecal bacterial enzymes, especially in older turkeys infected with APEC in a later stage of life. The continuous administration of monensin throughout the rearing period resulted in a weaker gastrointestinal response in older birds, compared with the other 2 antibiotics administered for the first 5 d of life. The results of the study are inconclusive as both desirable and undesirable effects of preventive early short-term antibiotic therapy were observed in turkeys, including normalization of ileal viscosity and cecal ammonia concentration (positive effect), and disruption in cecal SCFA production (negative effect).<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Enrofloxacin administration & dosage
Monensin administration & dosage
Monensin pharmacology
Male
Gastrointestinal Tract microbiology
Gastrointestinal Tract drug effects
Random Allocation
Turkeys
Escherichia coli Infections veterinary
Escherichia coli Infections drug therapy
Escherichia coli Infections microbiology
Poultry Diseases microbiology
Poultry Diseases drug therapy
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents pharmacology
Escherichia coli drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1525-3171
- Volume :
- 103
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Poultry science
- Publication Type :
- Academic Journal
- Accession number :
- 38652949
- Full Text :
- https://doi.org/10.1016/j.psj.2024.103720