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The diameter of cutaneous melanoma serves as a prognostic indicator for survival among acral-melanoma predominant East Asian patients.
- Source :
-
World journal of surgery [World J Surg] 2024 Jul; Vol. 48 (7), pp. 1692-1699. Date of Electronic Publication: 2024 Apr 23. - Publication Year :
- 2024
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Abstract
- Background: Tumor staging plays a pivotal role in melanoma management, where the depth of tumor invasion has been traditionally used as the cornerstone of staging. Paradoxically, the tumor diameter has not been integrated into the staging system. The aim of this study is to elucidate the clinical implications and prognostic value of tumor diameter in cutaneous melanoma, with a particular emphasis on the acral-melanoma predominant East Asian population, thus potentially enriching the clinical evaluation and treatment strategies for cutaneous melanoma.<br />Methods: From January 1 <superscript>st</superscript> , 2006 to December 31 <superscript>st</superscript> , 2022, a total of 352 patients were diagnosed with melanoma in our center. Among them, there were 135 patients diagnosed as cutaneous melanoma who received complete surgical wide excision and regional lymph nodes assessment. The diameter of the tumor, the depth of tumor invasion, lymph node status and patient survival were all collected and analyzed.<br />Results: The diameter of cutaneous melanoma had a weak positive correlation with tumor thickness (r = 0.26), however, it still had a significant predictive value for patients' overall survival (p = 0.005) and disease free survival (p = 0.023). As for lymph node metastasis prediction, the Breslow thickness had a better predictive value than tumor diameter (p = 0.002 vs. p = 0.565).<br />Conclusions: In this study, though with only weak positive correlation to tumor thickness, the tumor diameter of melanoma showed a statistically significant correlation with the patients' overall survival and disease free survival. However, the larger tumor diameter cannot be used as an indicator of high risk of lymph node metastasis.<br /> (© 2024 The Authors. World Journal of Surgery published by John Wiley & Sons Ltd on behalf of International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Young Adult
Asia, Eastern
East Asian People
Lymphatic Metastasis pathology
Melanoma, Cutaneous Malignant
Neoplasm Invasiveness pathology
Prognosis
Retrospective Studies
Survival Rate
Melanoma mortality
Melanoma pathology
Melanoma surgery
Neoplasm Staging
Skin Neoplasms pathology
Skin Neoplasms mortality
Skin Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2323
- Volume :
- 48
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- World journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38651933
- Full Text :
- https://doi.org/10.1002/wjs.12192