Bilateral Multiple Fractures Obstruct Quantitation of 99m Tc-Pyrophosphate Imaging for Cardiac Amyloidosis.

Abstract: A 57-year-old woman who had persistent symptoms of transthyretin cardiac amyloidosis underwent 99m Tc-pyrophosphate ( 99m Tc-PYP) scintigraphy. The 99m Tc-PYP planar and SPECT/CT fusion image showed diffuse myocardial uptake and multiple fractures of the sternum and ribs. These fractures interfered with semiquantitative scores of 99m Tc-PYP uptake, leading to false positive in 99m Tc-PYP imaging.
Competing Interests: Conflicts of interest and sources of funding: The current study was supported by the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD23016&2021HXFH033), and Quantitative parameters of 99m Tc-PYP SPECT/CT in the Diagnosis of Myocardial Amyloidosis (CGY2023-122).
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)