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Potential utility of pretreatment serum miRNAs for optimal treatment selection in advanced high-grade serous ovarian cancer.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2024 Aug 14; Vol. 54 (8), pp. 917-925. - Publication Year :
- 2024
-
Abstract
- Objective: The primary treatment of patients with advanced ovarian cancer is selected from whether primary debulking surgery or neoadjuvant chemotherapy. We investigated whether pretreatment serum microRNA profiles are useful for selecting patients with advanced high-grade serous ovarian cancer who obtain better outcomes from undergoing primary debulking surgery or neoadjuvant chemotherapy.<br />Methods: Consecutive patients with clinical stage IIIB-IVB and serum microRNA data were selected. Patients who underwent primary debulking surgery or neoadjuvant chemotherapy were subjected to 1:1 propensity score matching before comparing their progression-free survival using Cox modelling. Progression-free probabilities for the selected microRNA profiles were calculated, and the estimated progression-free survival with the recommended primary treatment was determined and compared with the actual progression-free survival of the patients.<br />Results: Of the 108 patients with stage IIIB-IVB disease, the data of 24 who underwent primary debulking surgery or neoadjuvant chemotherapy were compared. Eleven and three microRNAs were independent predictors of progression-free survival in patients who underwent primary debulking surgery and neoadjuvant chemotherapy, respectively. Two microRNAs correlated significantly with complete resection of the tumours in primary debulking surgery. No differences were found between the actual and estimated progression-free survival in the primary debulking surgery and neoadjuvant chemotherapy groups (P > 0.05). The recommended and actual primary treatments were identical in 27 (56.3%) of the 48 patients. The median improved survival times between recommended and actual treatment were 11.7 and 32.6 months for patients with actual primary debulking surgery and neoadjuvant chemotherapy, respectively.<br />Conclusions: Pretreatment microRNA profiles could be used to select subgroups of patients who benefited more from primary debulking surgery or neoadjuvant chemotherapy and might contribute to selecting the optimal primary treatment modality in advanced high-grade serous ovarian cancer patients.<br /> (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Humans
Female
Middle Aged
Aged
Neoplasm Grading
Adult
Biomarkers, Tumor blood
Biomarkers, Tumor genetics
Neoplasm Staging
Patient Selection
Progression-Free Survival
Ovarian Neoplasms blood
Ovarian Neoplasms therapy
Ovarian Neoplasms genetics
Ovarian Neoplasms pathology
Ovarian Neoplasms drug therapy
MicroRNAs blood
Cystadenocarcinoma, Serous blood
Cystadenocarcinoma, Serous genetics
Cystadenocarcinoma, Serous therapy
Cystadenocarcinoma, Serous pathology
Cystadenocarcinoma, Serous drug therapy
Cystadenocarcinoma, Serous surgery
Cytoreduction Surgical Procedures
Neoadjuvant Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 54
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 38651188
- Full Text :
- https://doi.org/10.1093/jjco/hyae051