Back to Search
Start Over
Substance P in the medial amygdala regulates aggressive behaviors in male mice.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Oct; Vol. 49 (11), pp. 1689-1699. Date of Electronic Publication: 2024 Apr 22. - Publication Year :
- 2024
-
Abstract
- Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykinin-expressing neurons in the medial amygdala (MeA <superscript>Tac1</superscript> neurons) are activated during aggressive behaviors in male mice. We identified MeA <superscript>Tac1</superscript> neurons as a key mediator of aggression and found that MeA <superscript>Tac1</superscript> →ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl) projections are critical to the regulation of aggression. Moreover, SP/neurokinin-1 receptor (NK-1R) signaling in the VMHvl modulates aggressive behaviors in male mice. SP/NK-1R signaling regulates aggression by influencing glutamate transmission in neurons in the VMHvl. In summary, these findings place SP as a key node in aggression circuits.<br /> (© 2024. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
- Subjects :
- Animals
Male
Mice
Receptors, Neurokinin-1 metabolism
Neurons physiology
Neurons metabolism
Tachykinins metabolism
Ventromedial Hypothalamic Nucleus physiology
Ventromedial Hypothalamic Nucleus metabolism
Ventromedial Hypothalamic Nucleus drug effects
Glutamic Acid metabolism
Neural Pathways physiology
Aggression physiology
Substance P metabolism
Corticomedial Nuclear Complex physiology
Corticomedial Nuclear Complex metabolism
Corticomedial Nuclear Complex drug effects
Mice, Inbred C57BL
Subjects
Details
- Language :
- English
- ISSN :
- 1740-634X
- Volume :
- 49
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 38649427
- Full Text :
- https://doi.org/10.1038/s41386-024-01863-w