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Tumor-Targeted Perfluorinated Micelles as Efficient Theranostic Agents Combining Positron Emission Tomography and Radiosensitization.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 May 01; Vol. 16 (17), pp. 21557-21570. Date of Electronic Publication: 2024 Apr 22. - Publication Year :
- 2024
-
Abstract
- We report the synthesis of biocompatible perfluorinated micelles designed to improve radiotherapeutic efficacy in a radioresistant tumor environment. In vitro and in vivo behaviors of perfluorinated micelles were assessed at both cellular and tissular levels. The micellar platform offers key advantages as theranostic tool: (i) small size, allowing deep tissue penetration; (ii) oxygen transport to hypoxic tissues; (iii) negligible toxicity in the absence of ionizing radiation; (iv) internalization into cancer cells; (v) potent radiosensitizing effect; and (vi) excellent tumor-targeting properties, as monitored by positron emission tomography. We have demonstrated strong in vitro radiosensitizing effects of the micelle and in vivo tumor targeting, making this nanometric carrier a promising tool for the potentiation of focused radiotherapy.
- Subjects :
- Animals
Humans
Mice
Cell Line, Tumor
Fluorocarbons chemistry
Fluorocarbons pharmacology
Neoplasms diagnostic imaging
Neoplasms drug therapy
Neoplasms pathology
Micelles
Positron-Emission Tomography
Radiation-Sensitizing Agents chemistry
Radiation-Sensitizing Agents pharmacology
Radiation-Sensitizing Agents chemical synthesis
Theranostic Nanomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 16
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 38648555
- Full Text :
- https://doi.org/10.1021/acsami.4c00910