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Management of corneal neovascularization: Current and emerging therapeutic approaches.

Authors :
Wu D
Chan KE
Lim BXH
Lim DK
Wong WM
Chai C
Manotosh R
Lim CHL
Source :
Indian journal of ophthalmology [Indian J Ophthalmol] 2024 May 01; Vol. 72 (Suppl 3), pp. S354-S371. Date of Electronic Publication: 2024 Apr 20.
Publication Year :
2024

Abstract

Corneal neovascularization (CoNV) is a sight-threatening condition affecting an estimated 1.4 million people per year, and the incidence is expected to rise. It is a complication of corneal pathological diseases such as infective keratitis, chemical burn, corneal limbal stem cell deficiency, mechanical trauma, and immunological rejection after keratoplasties. CoNV occurs due to a disequilibrium in proangiogenic and antiangiogenic mediators, involving a complex system of molecular interactions. Treatment of CoNV is challenging, and no therapy thus far has been curative. Anti-inflammatory agents such as corticosteroids are the mainstay of treatment due to their accessibility and well-studied safety profile. However, they have limited effectiveness and are unable to regress more mature neovascularization. With the advent of advanced imaging modalities and an expanding understanding of its pathogenesis, contemporary treatments targeting a wide array of molecular mechanisms and surgical options are gaining traction. This review aims to summarize evidence regarding conventional and emerging therapeutic options for CoNV.<br /> (Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.)

Details

Language :
English
ISSN :
1998-3689
Volume :
72
Issue :
Suppl 3
Database :
MEDLINE
Journal :
Indian journal of ophthalmology
Publication Type :
Academic Journal
Accession number :
38648452
Full Text :
https://doi.org/10.4103/IJO.IJO_3043_23