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Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension.

Authors :
Rao RJ
Chan SY
Source :
Circulation [Circulation] 2024 Apr 23; Vol. 149 (17), pp. 1372-1374. Date of Electronic Publication: 2024 Apr 22.
Publication Year :
2024

Abstract

Competing Interests: Disclosures Dr Chan has served as a consultant for Merck, Janssen, and United Therapeutics. Dr Chan is a director, officer, and shareholder in Synhale Therapeutics; has held grants from United Therapeutics, Bayer, and the WoodNext Foundation; and has filed patent applications for metabolism and next-generation therapeutics in PH. R.J. Rao reports no conflicts.

Details

Language :
English
ISSN :
1524-4539
Volume :
149
Issue :
17
Database :
MEDLINE
Journal :
Circulation
Publication Type :
Report
Accession number :
38648276
Full Text :
https://doi.org/10.1161/CIRCULATIONAHA.124.068738