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Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension.
- Source :
-
Circulation [Circulation] 2024 Apr 23; Vol. 149 (17), pp. 1372-1374. Date of Electronic Publication: 2024 Apr 22. - Publication Year :
- 2024
-
Abstract
- Competing Interests: Disclosures Dr Chan has served as a consultant for Merck, Janssen, and United Therapeutics. Dr Chan is a director, officer, and shareholder in Synhale Therapeutics; has held grants from United Therapeutics, Bayer, and the WoodNext Foundation; and has filed patent applications for metabolism and next-generation therapeutics in PH. R.J. Rao reports no conflicts.
- Subjects :
- Humans
Animals
Endothelium, Vascular metabolism
Endothelium, Vascular drug effects
Endothelial Cells metabolism
Endothelial Cells drug effects
Adenosine metabolism
Signal Transduction drug effects
Energy Metabolism drug effects
Hypertension, Pulmonary metabolism
Hypertension, Pulmonary drug therapy
Malate Dehydrogenase metabolism
Malate Dehydrogenase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4539
- Volume :
- 149
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Report
- Accession number :
- 38648276
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.124.068738