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Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 2024 Jul 12; Vol. 217 (2), pp. 159-166. - Publication Year :
- 2024
-
Abstract
- Apart from serving as a Th1 lineage commitment regulator, transcription factor T-bet is also expressed in other immune cell types and thus orchestrates their functions. In case of B cells, more specifically, T-bet is responsible for their isotype switching to specific IgG sub-classes (IgG2a/c in mice and IgG1/3 in humans). In various autoimmune disorders, such as systemic lupus erythematosus and/or rheumatoid arthritis, subsets of T-bet expressing B cells, known as age-associated B cells (CD19+CD11c+CD21-T-bet+) and/or double-negative B cells (CD19+IgD-CD27-T-bet+), display an expansion and seem to drive disease pathogenesis. According to data, mostly derived from mice models of autoimmunity, the targeting of these specific B-cell populations is capable of ameliorating the general health status of the autoimmune subjects. Here, in this review article, we present a variety of therapeutic approaches for both mice and humans, suffering from an autoimmune disease, and we discuss the effects of each approach on T-bet+ B cells. In general, we highlight the importance of specifically targeting T-bet+ B cells for therapeutic interventions in autoimmunity.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our siteāfor further information please contact journals.permissions@oup.com.)
- Subjects :
- Humans
Animals
Mice
Lupus Erythematosus, Systemic immunology
Lupus Erythematosus, Systemic therapy
Disease Models, Animal
T-Box Domain Proteins metabolism
T-Box Domain Proteins immunology
T-Box Domain Proteins genetics
Autoimmunity immunology
B-Lymphocytes immunology
Autoimmune Diseases immunology
Autoimmune Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2249
- Volume :
- 217
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 38647337
- Full Text :
- https://doi.org/10.1093/cei/uxae036