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C-peptide index at 2 h post-meal is a useful predictor of endogenous insulin secretory capacity and withdrawal from insulin therapy in subjects with type 2 diabetes.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Jul; Vol. 26 (7), pp. 2761-2773. Date of Electronic Publication: 2024 Apr 22. - Publication Year :
- 2024
-
Abstract
- Aims: To evaluate the correlation between C-peptide index (CPI) at 2 h post-meal and endogenous insulin secretory capacity and to develop clinical models to predict the possibility of withdrawal from insulin therapy in patients with type 2 diabetes.<br />Method: This was a single-centre retrospective study of patients with type 2 diabetes admitted to our hospital. Patients were divided into a withdrawal group (n = 72) and a non-withdrawal group (n = 75) based on whether they were able to withdraw from insulin therapy at discharge, and the correlation between CPI at 2 h after meal and diabetes-related parameters was evaluated. In addition, we created two clinical models to predict the possibility of withdrawal from insulin therapy using machine learning.<br />Results: The glycated haemoglobin values of the study participants were 87.8 ± 22.6 mmol/mo. The CPI at 2 h post-meal was 1.93 ± 1.28 in the non-withdrawal group and 2.97 ± 2.07 in the withdrawal group (p < 0.001). CPI at 2 h post-meal was an independent predictor of withdrawal from insulin therapy. In addition, CPI at 2 h post-meal was a better predictor than fasting CPI. Six factors associated with insulin therapy withdrawal (age, duration of diabetes, creatinine, alanine aminotransferase, insulin therapy until hospitalization, and CPI at 2 h post-meal) were used to generate two clinical models by machine learning. The accuracy of the generated clinical models ranged from 78.3% to 82.6%.<br />Conclusion: The CPI at 2 h post-meal is a clinically useful measure of endogenous insulin secretory capacity under non-fasting conditions.<br /> (© 2024 John Wiley & Sons Ltd.)
- Subjects :
- Humans
Male
Female
Middle Aged
Retrospective Studies
Aged
Glycated Hemoglobin analysis
Glycated Hemoglobin metabolism
Withholding Treatment statistics & numerical data
Machine Learning
Meals
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 blood
C-Peptide blood
Postprandial Period
Insulin therapeutic use
Insulin administration & dosage
Insulin Secretion
Hypoglycemic Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 38646845
- Full Text :
- https://doi.org/10.1111/dom.15595