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Usefulness of the C-Reactive Protein (CRP)-Albumin-Lymphocyte (CALLY) Index as a Prognostic Indicator for Patients With Gastric Cancer.
- Source :
-
The American surgeon [Am Surg] 2024 Nov; Vol. 90 (11), pp. 2703-2709. Date of Electronic Publication: 2024 Apr 21. - Publication Year :
- 2024
-
Abstract
- Background: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel immune nutrition scoring system associated with cancer prognosis. This study investigated the association between the CALLY index and the long-term outcomes of patients with gastric cancer.<br />Methods: We included 175 patients with gastric cancer who underwent curative gastrectomies at the Department of Surgery, International University of Health and Welfare Hospital between January 2011 and October 2019. The CALLY index was calculated based on the levels of serum albumin, serum CRP, and peripheral lymphocyte count. Utilizing both univariate and multivariate analyses, the prognostic value of the CALLY index was investigated.<br />Results: In the multivariate analyses, disease stage (hazard ratio [HR], 7.85; 95% confidence interval [CI], 3.31-18.6; P < .01), microvascular invasion (HR, 2.88; 95% CI, 1.30-6.36; P < .01), and low CALLY index (HR, 2.18; 95% CI, 1.00-4.76; P = .05) were independent and significant predictors of disease-free survival. Low body mass index (HR, 4.15; 95% CI, 1.63-10.6; P < .01), advanced disease stage (HR, 8.22; 95% CI, 3.47-19.5; P < .01), and low CALLY index (HR, 3.00; 95% CI, 1.3-6.93; P = .01) were independent and significant predictors of overall survival. The low CALLY index group had a lower body mass index ( P < .01), advanced disease stage ( P < .01), and a higher Glasgow prognostic score ( P < .01).<br />Conclusions: The CALLY index may be associated with a poor prognosis for gastric cancer, highlighting the utility of a comprehensive assessment using inflammatory, nutritional, and immunological statuses.<br />Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Male
Female
Prognosis
Middle Aged
Aged
Lymphocyte Count
Retrospective Studies
Neoplasm Staging
Lymphocytes
Disease-Free Survival
Adult
Biomarkers, Tumor blood
Stomach Neoplasms mortality
Stomach Neoplasms surgery
Stomach Neoplasms blood
Stomach Neoplasms pathology
C-Reactive Protein analysis
Serum Albumin analysis
Gastrectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1555-9823
- Volume :
- 90
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The American surgeon
- Publication Type :
- Academic Journal
- Accession number :
- 38644521
- Full Text :
- https://doi.org/10.1177/00031348241248693