Towards fair and clinically relevant polygenic predictions.

Authors :: Vilhjálmsson BJ
Source :: Trends in genetics : TIG [Trends Genet] 2024 May; Vol. 40 (5), pp. 379-380. Date of Electronic Publication: 2024 Apr 19.
Publication Year :: 2024
Abstract: Lennon et al. recently proposed a clinical polygenic score (PGS) pipeline as part of the Electronic Medical Records and Genomics (eMERGE) network initiative. In this spotlight article we discuss the broader context for the use of PGS in preventive medicine and highlight key limitations and challenges facing their inclusion in prediction models.<br />Competing Interests: Declaration of interests B.J.V. is a member of the scientific advisory board for Allelica.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)