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Age-specific prevalence of IgG against measles/rubella and the impact of routine and supplementary immunization activities: A multistage random cluster sampling study with mathematical modelling.
- Source :
-
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jul; Vol. 144, pp. 107053. Date of Electronic Publication: 2024 Apr 17. - Publication Year :
- 2024
-
Abstract
- Background: Vietnam continues to have measles and rubella outbreaks following supplementary immunization activities (SIA) and routine immunization despite both having high reported coverage. To evaluate immunization activities, age-specific immunity against measles and rubella, and the number of averted Congenital Rubella Syndrome (CRS) cases, must be estimated.<br />Methods: Dried blood spots were collected from 2091 randomly selected individuals aged 1-39 years. Measles and rubella virus-specific immunoglobulin G (IgG) were measured by enzyme immunoassay. Results were considered positive at ≥120 mIU/mL for measles and ≥10 IU/mL for rubella. The number of CRS cases averted by immunization since 2014 were estimated using mathematical modelling.<br />Results: Overall IgG seroprevalence was 99.7% (95%CI: 99.2-99.9) for measles and 83.6% (95%CI: 79.3-87.1) for rubella. Rubella IgG seroprevalence was higher among age groups targeted in the SIA than in non-targeted young adults (95.4% [95%CI: 92.9-97.0] vs 72.4% [95%CI: 63.1-80.1]; P < 0.001). The estimated number of CRS cases averted in 2019 by immunization activities since 2014 ranged from 126 (95%CI: 0-460) to 883 (95%CI: 0-2271) depending on the assumed postvaccination reduction in the force of infection.<br />Conclusions: The results suggest the SIA was effective, while young adults born before 1998 who remain unprotected for rubella require further vaccination.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Humans
Adolescent
Child, Preschool
Child
Adult
Male
Seroepidemiologic Studies
Female
Young Adult
Infant
Models, Theoretical
Rubella Vaccine immunology
Rubella Vaccine administration & dosage
Rubella virus immunology
Prevalence
Measles Vaccine immunology
Measles Vaccine administration & dosage
Age Factors
Vaccination
Immunization Programs
Rubella Syndrome, Congenital epidemiology
Rubella Syndrome, Congenital prevention & control
Rubella Syndrome, Congenital immunology
Immunoglobulin G blood
Measles epidemiology
Measles prevention & control
Measles immunology
Rubella epidemiology
Rubella immunology
Rubella prevention & control
Antibodies, Viral blood
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3511
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 38641317
- Full Text :
- https://doi.org/10.1016/j.ijid.2024.107053