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Warfarin dosage in a postpartum woman while breastfeeding: A case report.

Warfarin dosage in a postpartum woman while breastfeeding: A case report.

Authors :
Uppuluri E
Idrees N
Shapiro N
Source :
Pharmacotherapy [Pharmacotherapy] 2024 Apr; Vol. 44 (4), pp. 343-347. Date of Electronic Publication: 2024 Apr 17.
Publication Year :
2024

Abstract

Warfarin is the only oral anticoagulant recommended in women who are breastfeeding. Although warfarin is a compatible and recommended agent in the postpartum period and during lactation, little is known regarding changes to warfarin dose requirements in this patient population. Here, we report the case of a 40-year-old woman who transitioned from enoxaparin monotherapy back to warfarin at 2 months postpartum, while she was breastfeeding. Despite resuming warfarin at her previously therapeutic dose, her international normalized ratio (INR) remained subtherapeutic and required multiple dose increases. She ultimately required a 100% increase in her warfarin dose postpartum, compared to pre-pregnancy, to achieve a therapeutic INR. This case suggests patients may require higher warfarin doses postpartum, compared to pre-pregnancy, especially if breastfeeding. Clinicians should closely monitor these patients and adjust warfarin doses as necessary.<br /> (© 2024 The Authors. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy published by Wiley Periodicals LLC on behalf of Pharmacotherapy Publications, Inc.)

Details

Language :
English
ISSN :
1875-9114
Volume :
44
Issue :
4
Database :
MEDLINE
Journal :
Pharmacotherapy
Publication Type :
Academic Journal
Accession number :
38634189
Full Text :
https://doi.org/10.1002/phar.2917