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Warfarin dosage in a postpartum woman while breastfeeding: A case report.
Warfarin dosage in a postpartum woman while breastfeeding: A case report.
- Source :
-
Pharmacotherapy [Pharmacotherapy] 2024 Apr; Vol. 44 (4), pp. 343-347. Date of Electronic Publication: 2024 Apr 17. - Publication Year :
- 2024
-
Abstract
- Warfarin is the only oral anticoagulant recommended in women who are breastfeeding. Although warfarin is a compatible and recommended agent in the postpartum period and during lactation, little is known regarding changes to warfarin dose requirements in this patient population. Here, we report the case of a 40-year-old woman who transitioned from enoxaparin monotherapy back to warfarin at 2 months postpartum, while she was breastfeeding. Despite resuming warfarin at her previously therapeutic dose, her international normalized ratio (INR) remained subtherapeutic and required multiple dose increases. She ultimately required a 100% increase in her warfarin dose postpartum, compared to pre-pregnancy, to achieve a therapeutic INR. This case suggests patients may require higher warfarin doses postpartum, compared to pre-pregnancy, especially if breastfeeding. Clinicians should closely monitor these patients and adjust warfarin doses as necessary.<br /> (© 2024 The Authors. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy published by Wiley Periodicals LLC on behalf of Pharmacotherapy Publications, Inc.)
- Subjects :
- Humans
Female
Adult
Dose-Response Relationship, Drug
Enoxaparin administration & dosage
Enoxaparin adverse effects
Enoxaparin therapeutic use
Warfarin administration & dosage
Warfarin adverse effects
Breast Feeding
Anticoagulants administration & dosage
Anticoagulants adverse effects
Postpartum Period
International Normalized Ratio
Subjects
Details
- Language :
- English
- ISSN :
- 1875-9114
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 38634189
- Full Text :
- https://doi.org/10.1002/phar.2917