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Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair.

Authors :
Yin W
Yang C
Liu D
Cha S
Cai L
Ye G
Song X
Zhang J
Qiu X
Source :
Biomedical materials (Bristol, England) [Biomed Mater] 2024 Apr 30; Vol. 19 (3). Date of Electronic Publication: 2024 Apr 30.
Publication Year :
2024

Abstract

It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease of production, multi-scale porous structure, high flexibility, and excellent biocompatibility. By utilizing the reducing properties of polydopamine, non-conductive graphene oxide (GO) was converted into conductive reduced graphene oxide (rGO) and crosslinked in situ within the mussel shells. In vitro experiments confirmed that this multi-scale porous Shell@PDA-GO could serve as structural cues for enhancing cell adhesion, differentiation, and maturation, as well as promoting the electrophysiological development of hippocampal neurons. After transplantation at the injury sites, the Shell@PDA-GO provided a pro-regenerative microenvironment, promoting endogenous neurogenesis, triggering neovascularization, and relieving glial fibrosis formation. Interestingly, the Shell@PDA-GO could induce the release of endogenous growth factors (NGF and NT-3), resulting in the complete regeneration of nerve fibers at 12 weeks. This work provides a feasible strategy for the exploration of conductive multi-scale patterned scaffold to repair SCI.<br /> (© 2024 IOP Publishing Ltd.)

Details

Language :
English
ISSN :
1748-605X
Volume :
19
Issue :
3
Database :
MEDLINE
Journal :
Biomedical materials (Bristol, England)
Publication Type :
Academic Journal
Accession number :
38626779
Full Text :
https://doi.org/10.1088/1748-605X/ad3f63