Back to Search Start Over

Small-cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview.

Small-cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview.

Authors :
Saraei P
Heshmati A
Hosseini S
Source :
Journal of neuroendocrinology [J Neuroendocrinol] 2024 Jun; Vol. 36 (6), pp. e13394. Date of Electronic Publication: 2024 Apr 16.
Publication Year :
2024

Abstract

Small-cell neuroendocrine carcinomas (SCNECs) of the female genital tract are rare and aggressive tumors that are characterized by a high rate of recurrence and poor prognosis. They can arise from various sites within the female genital tract, including the cervix, endometrium, ovary, fallopian tube, vagina, and vulva. They are composed of cells with neuroendocrine features, such as the ability to produce and secrete hormones and peptides, and a high mitotic rate. Immunohistochemical staining for neuroendocrine markers, such as chromogranin A, synaptophysin, and CD56, can aid in the diagnosis of these tumors. This article provides an overview of the epidemiology, etiology, and risk factors associated with these tumors, as well as their clinical presentation, cellular characteristics, diagnosis, and finally the current treatment options for SCNECs, including surgery, chemotherapy, and radiation therapy, alone or in combination.<br /> (© 2024 British Society for Neuroendocrinology.)

Details

Language :
English
ISSN :
1365-2826
Volume :
36
Issue :
6
Database :
MEDLINE
Journal :
Journal of neuroendocrinology
Publication Type :
Academic Journal
Accession number :
38626758
Full Text :
https://doi.org/10.1111/jne.13394