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Ultrasensitive CCL2 Detection in Urine for Diabetic Nephropathy Diagnosis Using a WS 2 -Based Plasmonic Biosensor.
- Source :
-
Nano letters [Nano Lett] 2024 May 01; Vol. 24 (17), pp. 5301-5307. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- The accurate diagnosis of diabetic nephropathy relies on achieving ultrasensitive biosensing for biomarker detection. However, existing biosensors face challenges such as poor sensitivity, complexity, time-consuming procedures, and high assay costs. To address these limitations, we report a WS <subscript>2</subscript> -based plasmonic biosensor for the ultrasensitive detection of biomarker candidates in clinical human urine samples associated with diabetic nephropathy. Leveraging plasmonic-based electrochemical impedance microscopy (P-EIM) imaging, we observed a remarkable charge sensitivity in monolayer WS <subscript>2</subscript> single crystals. Our biosensor exhibits an exceptionally low detection limit (0.201 ag/mL) and remarkable selectivity in detecting CC chemokine ligand 2 (CCL2) protein biomarkers, outperforming conventional techniques such as ELISA. This work represents a breakthrough in traditional protein sensors, providing a direction and materials foundation for developing ultrasensitive sensors tailored to clinical applications for biomarker sensing.
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 24
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 38625005
- Full Text :
- https://doi.org/10.1021/acs.nanolett.4c00981