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Neural Processing without O 2 and Glucose Delivery: Lessons from the Pond to the Clinic.
- Source :
-
Physiology (Bethesda, Md.) [Physiology (Bethesda)] 2024 Nov 01; Vol. 39 (6), pp. 0. Date of Electronic Publication: 2024 Apr 16. - Publication Year :
- 2024
-
Abstract
- Neuronal activity requires a large amount of ATP, leading to a rapid collapse of brain function when aerobic respiration fails. Here, we summarize how rhythmic motor circuits in the brain stem of adult frogs, which normally have high metabolic demands, transform to produce proper output during severe hypoxia associated with emergence from hibernation. We suggest that general principles underlying plasticity in brain bioenergetics may be uncovered by studying nonmammalian models that face extreme environments, yielding new insights to combat neurological disorders involving dysfunctional energy metabolism.
Details
- Language :
- English
- ISSN :
- 1548-9221
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Physiology (Bethesda, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 38624246
- Full Text :
- https://doi.org/10.1152/physiol.00030.2023