First-trimester exposure to tofacitinib in ulcerative colitis: A case report of a healthy newborn and literature review.

Tofacitinib is contraindicated in pregnancy. We present a patient with ulcerative colitis on tofacitinib who had an unplanned pregnancy. Tofacitinib was ceased, switched to vedolizumab, and she gave birth to a healthy newborn at term. Case reports of reassuring outcomes provide real-world data that assists decision-making for future patients.
Competing Interests: Rupert W. Leong reports advisory board membership of AbbVie, Aspen, BMS, Celgene, Celltrion, Chiesi, Ferring, Glutagen, Hospira, Janssen, Lilly, MSW, Novartis, Pfizer, Prometheus Biosciences, Takeda and research grant support from McCusker Charitable Foundation, Joanna Tiddy grant University of Sydney, Celltrion, Shire, Janssen, Takeda, Gastroenterological Society of Australia, MRFF, NHMRC, Gutsy Group, Pfizer. All the other authors have no conflict of interest to declare.
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