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Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study.

Authors :
Wu Y
Deng YL
Zhang M
Miao Y
Cui FP
Zeng JY
Liu XY
Li CR
Liu AX
Zhu JQ
Li YJ
Liu C
Zeng Q
Source :
The Science of the total environment [Sci Total Environ] 2024 Jun 01; Vol. 927, pp. 172368. Date of Electronic Publication: 2024 Apr 12.
Publication Year :
2024

Abstract

Background: Disinfection byproducts (DBPs) have been shown to impair thyroid function in experimental models. However, epidemiological evidence is scarce.<br />Methods: This study included 1190 women undergoing assisted reproductive technology (ART) treatment from the Tongji Reproductive and Environmental (TREE) cohort from December 2018 to August 2021. Serum thyrotropin (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured as indicators of thyroid function. FT4/FT3 and TSH/FT4 ratios were calculated as markers of thyroid hormone homeostasis. Dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA), the two most abundant HAAs, in urine were detected to assess individual DBP exposures.<br />Results: After adjusting for relevant covariates, positive associations were observed between urinary TCAA concentrations and serum TSH and TSH/FT4 levels (e.g., percent change = 5.82 %, 95 % CI: 0.70 %, 11.21 % for TSH), whereas inverse associations were found for serum FT3 and FT4 (e.g., percent change = -1.29 %, 95 % CI: -2.49 %, -0.07 % for FT3). There also was a negative association between urinary DCAA concentration and serum FT4/FT3 (percent change = -2.49 %, 95 % CI: -4.71 %, -0.23 %). These associations were further confirmed in the restricted cubic spline and generalized additive models with linear or U-shaped dose-response relationships.<br />Conclusion: Urinary HAAs were associated with altered thyroid hormone homeostasis among women undergoing ART treatment.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-1026
Volume :
927
Database :
MEDLINE
Journal :
The Science of the total environment
Publication Type :
Academic Journal
Accession number :
38614346
Full Text :
https://doi.org/10.1016/j.scitotenv.2024.172368