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SOX-10 and TRP-1 expression in feline ocular and nonocular melanomas.
- Source :
-
Veterinary pathology [Vet Pathol] 2024 Sep; Vol. 61 (5), pp. 712-720. Date of Electronic Publication: 2024 Apr 13. - Publication Year :
- 2024
-
Abstract
- In felines, ocular and nonocular melanomas are uncommon tumors that represent a diagnostic challenge for pathologists, especially when amelanotic. To date, the immunohistochemical diagnostic panel in cats is based on specific melanocytic markers (Melan-A and PNL2) and a nonspecific but sensitive marker (S100). In human medicine, SOX-10 is reported to be a sensitive antibody for the detection of melanoma micrometastasis in the lymph node. TRP-1, an enzyme involved in melanogenesis, has recently been used in humans and dogs as a specific melanocyte marker. The aim of this study was to evaluate the cross-reactivity and the expression of SOX-10 and TRP-1 antibodies in feline normal tissue and melanocytic tumors. Thirty-one cases of ocular, cutaneous, and oral melanomas were retrospectively evaluated and confirmed by histopathological examination and by immunolabeling with Melan-A and/or PNL2. SOX-10 nuclear expression in normal tissues was localized in epidermal, subepidermal, hair bulb, and iridal stromal melanocytes and dermal nerves. In melanomas, nuclear expression of SOX-10 was detected in ocular (11/12; 92%), oral (6/7; 86%), and cutaneous sites (12/12; 100%). TRP-1 cytoplasmic immunolabeling in normal tissue was observed in epidermal and bulbar melanocytes and in the lining pigmented epithelium of the iris and in its stroma. Its expression was positively correlated to the degree of pigmentation in the tumor and was observed in 75% of ocular (9/12), 43% of oral (3/7), and 33% of cutaneous melanomas (4/12). This study demonstrated the cross-reactivity of SOX-10 and TRP-1 antibodies in feline non-neoplastic melanocytes and their expression in ocular and nonocular melanomas.<br />Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Animals
Cats
Retrospective Studies
Biomarkers, Tumor metabolism
Female
Immunohistochemistry veterinary
Male
Melanocytes pathology
Melanocytes metabolism
Skin Neoplasms veterinary
Skin Neoplasms pathology
Skin Neoplasms metabolism
Cross Reactions
Mouth Neoplasms veterinary
Mouth Neoplasms pathology
Mouth Neoplasms metabolism
Intramolecular Oxidoreductases
Melanoma veterinary
Melanoma pathology
Melanoma metabolism
SOXE Transcription Factors metabolism
Cat Diseases pathology
Cat Diseases metabolism
Eye Neoplasms veterinary
Eye Neoplasms pathology
Eye Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 38613415
- Full Text :
- https://doi.org/10.1177/03009858241244850