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Elevation of S2-bound α1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma.
- Source :
-
Journal of viral hepatitis [J Viral Hepat] 2024 Jul; Vol. 31 (7), pp. 383-390. Date of Electronic Publication: 2024 Apr 12. - Publication Year :
- 2024
-
Abstract
- There is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). Åström et al. suggested that S2-bound α1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC® ELISA kit (Glycobond AB, Linköping, SE) at the start of treatment, end of treatment and follow-up (maximum: 78 months). Patients were retrospectively propensity score matched (1:2). Thirty-one patients chronically infected with HCV developed HCC after a sustained virological response, while 62 did not. In addition, samples of patients with chronic hepatitis B virus infection, metabolic dysfunction-associated steatotic liver disease and HCC of different etiologies were analysed. S2-bound AGP elevation in HCC patients was confirmed. However, we did not observe a predictive advantage of S2-bound AGP for the early detection of HCC during treatment and follow-up. Interestingly, S2-bound AGP levels correlated with aspartate aminotransferase (ρ = .56, p = 9.5×10 <superscript>-15</superscript> ) and liver elastography (ρ = .67, p = 2.2×10 <superscript>-16</superscript> ). Of note, S2-bound AGP decreased in patients chronically infected with HCV after treatment-induced HCV clearance. Fucosylated S2-bound AGP levels were elevated in patients with chronic HCV and HCC. The potential role of S2-bound AGP as a novel tumour marker requires further investigation.<br /> (© 2024 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Antiviral Agents therapeutic use
Biomarkers, Tumor metabolism
Case-Control Studies
Early Detection of Cancer
Hepacivirus
Retrospective Studies
Biomarkers blood
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular etiology
Hepatitis C, Chronic complications
Hepatitis C, Chronic diagnosis
Liver Neoplasms diagnosis
Liver Neoplasms etiology
Orosomucoid metabolism
Orosomucoid analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2893
- Volume :
- 31
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of viral hepatitis
- Publication Type :
- Academic Journal
- Accession number :
- 38610115
- Full Text :
- https://doi.org/10.1111/jvh.13943